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Target intelligence / Profile preview
Glial cell-line derived neurotrophic factor family receptor alpha RET (RET)
- Target
- RET
- Molecular classification
- Receptor Tyrosine Kinase, RTK
01
Overview
RET functions as a central hub integrating signals from diverse neurotrophic factors through multi-protein complexes involving both soluble ligands from the GDNF family and membrane-bound co-receptors from the GFRα family. Its unique structural features enable flexible responses that are critical during development but also render it susceptible to oncogenic transformation when mutated or dysregulated.
- Other names
- RET proto-oncogenec-RetProto-oncogene c-RetMEN2AMEN2BHSCR1
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Cell proliferationCell differentiationCell survivalCell migrationKidney morphogenesisNervous system developmentSignal transduction
04
Disease associations
Medullary thyroid carcinoma (MTC)Multiple endocrine neoplasia type 2 (MEN 2)Hirschsprung’s diseaseCancer
05
Safety considerations
On-target toxicityOff-target effectsResistance development
06
Biomarkers
RET mutations (e.g., in MTC and MEN2)RET fusionRET phosphorylation status
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