Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glial Cell Line-Derived Neurotrophic Factor Receptor (GFRα)
- Target
- GFRα
- Molecular classification
- Receptor, GPI-anchored cell surface protein, TGF-beta superfamily
01
Overview
The glial cell line-derived neurotrophic factor receptor (GFRα) is a key component of the signaling complex for glial cell line-derived neurotrophic factor (GDNF), a protein crucial for neuronal survival and development. Upon ligand binding, GFRα forms a complex with RET tyrosine kinase, triggering intracellular signaling cascades. It plays a critical role in the survival of dopaminergic neurons and motor neurons, kidney development, and modulation of glial activity. Targeting this receptor system has potential therapeutic applications in neurodegenerative diseases, neuropathic pain, and cancer.
- Other names
- GDNF ReceptorGFR alphaGFRα1GFRα2GFRα3GFRα4
02
Mechanism of action
Activation of ERK/MAPK, PI3K/AKT, and Src-family kinases pathways via RET tyrosine kinase upon ligand binding.
03
Biological functions
Neuron survivalNeuroprotectionAnti-apoptosisSignal transductionCell developmentModulation of glial activity
04
Disease associations
Parkinson's diseaseAmyotrophic Lateral Sclerosis (ALS)Neuropathic painNeurodegenerative diseaseCancer
05
Safety considerations
Potential for off-target effects due to interactions with other receptors (e.g., Met, NCAM).Tumor microenvironment modulation in certain cancers.
Beyond the preview
Go deeper on Glial Cell Line-Derived Neurotrophic Factor Receptor (GFRα).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glial Cell Line-Derived Neurotrophic Factor Receptor (GFRα).