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Glial cell line-derived neurotrophic factor receptor alpha like
- Molecular classification
- Receptor
01
Overview
GFRAL is a receptor that mediates the effects of growth differentiation factor 15 (GDF15), particularly in the central nervous system, specifically in the area postrema and nucleus tractus solitarius of the brainstem. Upon binding GDF15, GFRAL forms a complex with RET, activating intracellular pathways that influence metabolic processes, appetite, energy expenditure, and body weight regulation. The GDF15-GFRAL pathway has been implicated in cancer cachexia.
02
Mechanism of action
GFRAL antagonistic antibodies are in development; these block GDF15 binding and signaling.
03
Biological functions
Signal transductionAppetite regulationEnergy homeostasis
04
Disease associations
Cancer cachexia
05
Biomarkers
GDF15 (as a ligand for GFRAL)
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