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Target intelligence / Profile preview
Glial Fibrillary Acidic Protein (GFAP)
- Target
- GFAP
- Molecular classification
- Type III intermediate filament
01
Overview
Glial fibrillary acidic protein (GFAP) is a type III intermediate filament protein primarily expressed in astrocytes of the central nervous system. It plays a crucial role in providing structural support to astroglia, maintaining the blood-brain barrier integrity, and supporting neighboring neurons. GFAP is upregulated in response to CNS injury or disease, making it a valuable biomarker for various neurological conditions. Mutations in GFAP are associated with Alexander disease, a rare leukodystrophy. It is also explored as a therapeutic target given its implication in astrogliosis and neuroinflammation.
02
Biological functions
Cytoskeletal supportBlood-brain barrier maintenanceCell shape maintenanceAstroglia function regulation
03
Disease associations
Neurological injuryNeurodegenerationBrain tumorsAlexander diseaseNeuroinflammationPsychiatric disorders
04
Biomarkers
Traumatic brain injurySpinal cord injuryStrokeAstrocytomaEpendymomaNeurodegenerative diseases
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