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Target intelligence / Profile preview
Glioma-associated oncogene homologue protein 1 (GLI1)
- Target
- GLI1
- Molecular classification
- Transcription factor
01
Overview
Glioma-associated oncogene homologue 1 (GLI1) is a zinc finger transcription factor and a key effector of the Hedgehog (Hh) signaling pathway. It functions primarily as a transcriptional activator, regulating genes involved in cell cycle progression, migration, invasion, and survival. GLI1 overexpression is observed in various cancers, including gliomas and breast carcinomas, making it an attractive target for anti-cancer therapy. Targeting the Hh–Gli axis could impact tumor growth/survival across multiple cancer types.
- Other names
- Gli
02
Mechanism of action
Modulation or inhibition of the Hh-Gli axis
03
Biological functions
Signal transductionCell cycleCell proliferationCell survivalDifferentiationTranscriptional activation
04
Disease associations
Cancer
05
Safety considerations
Potential for developmental toxicity due to Hh pathway involvementGenomic instability
06
Biomarkers
lncRNAs
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