Glioma pathogenesis-related protein 1 (GLIPR1)

Glioma pathogenesis-related protein 1 (GLIPR1), also known as RTVP-1, is a member of the CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1) superfamily (UniProt Q9UCZ1). It is a membrane-anchored protein that exhibits complex, context-dependent roles in oncology, functioning as a tumor suppressor in prostate and lung cancers while promoting malignancy in glioblastomas (NCBI Gene ID: 11010). GLIPR1 influences several key biological pathways, including the induction of apoptosis, regulation of the cell cycle, and modulation of the immune microenvironment. In tumor-suppressive contexts, GLIPR1 promotes cell death by increasing reactive oxygen species (ROS) and activating p53-mediated signaling (Ren C, et al., 2011). Because of its potent pro-apoptotic activity when overexpressed in certain tumors, GLIPR1 has been investigated as a target for gene therapy. Specifically, adenoviral vectors carrying a truncated version of the GLIPR1 gene (Ad-GLIPR1-ΔTM) have been developed to induce selective apoptosis in cancer cells (Satoh T, et al., 2005).

Other names

RTVP1RTVP-1CRISP7GLIPRRelated to testes-specific, vespid, and pathogenesis protein 1

Induction of apoptosis through p53-dependent and independent pathways, stimulation of reactive oxygen species (ROS) production, and suppression of c-Myc signaling (Satoh T, et al., Cancer Research, 2005; Ren C, et al., Molecular Cancer, 2011).