GLIPR1-like protein 2 (GLIPR1L2)

GLIPR1-like protein 2 (GLIPR1L2) is a human protein-coding gene that belongs to the CAP (cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 protein) superfamily, closely related to the GLIPR1 (glioma pathogenesis-related protein 1) gene[1][3]. While the GLIPR1 gene product has been implicated in tumor biology with both tumor suppressor and oncogenic functions depending on cellular context, the specific biological function and disease associations of GLIPR1L2 are not well defined. GLIPR1L2 is primarily classified based on sequence similarity and predicted domain organization, possessing a CAP-like or SCP (sperm-coating protein)-like domain possibly involved in secretory or immune-related processes. Evidence from tissue expression data indicates presence in several tissues, including high mRNA levels in testes and lower or undetectable levels in various other organs[3]. Significant disease roles, drug interactions, or applications as a therapeutic biomarker or target have not been established for GLIPR1L2 itself as of the most recent data. Key context: - GLIPR1L2 is not well characterized beyond its classification in the CAP/CRISP protein family[1][3]. - There is extensive functional literature for GLIPR1 (the related gene/protein), but not for GLIPR1L2 specifically[1]. - Most available data for GLIPR1L2 come from gene expression analyses and protein atlas/mapping efforts, not functional or clinical studies[3]. - GLIPR1L2 is not currently recognized as a druggable or disease-validated target. If you require information on GLIPR1 or GLIPR1-like proteins more generally—including their roles in cancer, cell signaling, and potential as targets—refer to the related gene "GLIPR1" for more comprehensive literature[1][2][4].

Other names

GLIPR1L2Glioma pathogenesis-related protein 1-like protein 2