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Target intelligence / Profile preview
Globin Locus Regulatory Element (LCR)
- Target
- LCR
- Molecular classification
- Cis-regulatory element, DNA regulatory sequence, Enhancer
01
Overview
The globin locus regulatory element, or locus control region (LCR), is a long-range cis-regulatory DNA element that controls the expression of globin genes, particularly within the β-globin gene cluster. The LCR is essential for achieving high-level, tissue-specific expression of these genes in erythroid cells. It consists of several DNase I hypersensitive sites and enhances expression of linked globin genes at physiological levels. Its activity is highly tissue-specific, selectively activating β-globin gene transcription in erythroid cells. Disruption leads to diseases such as β-thalassemia.
- Other names
- Locus Control RegionBeta-globin LCRβ-globin LCR
02
Mechanism of action
N/A
03
Biological functions
Enhancer activityRegulation of gene expressionTissue-specific gene expressionChromatin remodelingLong-range transcriptional control
04
Disease associations
Beta-thalassemiaGenetic disorders of hemoglobin synthesis
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