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Globo H Antigen
- Molecular classification
- Glycosphingolipid, Tumor-associated carbohydrate antigen (TACA)
01
Overview
Globo H antigen is an oncogenic glycosphingolipid highly expressed on various carcinomas but not on healthy tissues. Its unique structure makes it both an important biomarker and therapeutic target—especially suited for antibody-based therapies and vaccines aimed at selectively attacking malignant cells while sparing normal ones. It facilitates immune evasion by suppressing T and B cell proliferation and cytokine secretion. Globo H serves as an attractive target for anticancer vaccines and antibody-based therapies.
- Other names
- globohexaosylceramide
02
Mechanism of action
Antibodies against Globo H can induce both IgG and IgM responses that recognize this epitope on tumor surfaces; these antibodies may mediate direct cytotoxicity or recruit other immune effector functions against tumors expressing Globo H.
03
Biological functions
Immune evasionSuppression of lymphocyte functionRegulation of Notch signaling
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects if Globo H is expressed in normal tissues (although expression is generally very low)Immune-related adverse events associated with immunotherapies
06
Interacting drugs
Adagloxad Simolenin (OBI-822)
1 more in the full profile.
07
Biomarkers
Globo H expression level in tumor tissue
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