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Glomerular Filtration Rate (GFR)
- Target
- GFR
- Molecular classification
- Physiological Measurement, Kidney Function Indicator
01
Overview
Glomerular filtration rate (GFR) is a clinical measurement used to assess kidney function. It estimates the volume of blood filtered by the glomeruli per unit time. GFR is the best overall indicator of kidney function, and is used for diagnosing and staging chronic kidney disease (CKD).
02
Mechanism of action
GFR is a measure, not a target. Drugs influence GFR by affecting renal hemodynamics, glomerular permeability, and tubular reabsorption/secretion.
03
Biological functions
Renal filtrationWaste removalFluid balance regulation
04
Disease associations
Chronic Kidney DiseaseAcute Kidney InjuryHypertensionDiabetesCardiovascular disease
05
Safety considerations
Overestimation or underestimation of GFR based on the estimation equation used.Variability in creatinine production based on muscle mass, diet, and other factors.Drug toxicity in patients with reduced GFR requiring dose adjustments.Contrast-induced nephropathy (CIN) risk during imaging procedures.Progression of CKD
06
Interacting drugs
ACE inhibitors
4 more in the full profile.
07
Biomarkers
Serum creatinineCystatin CUrine albumin-to-creatinine ratio (UACR)Blood urea nitrogen (BUN)
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