Glucan-binding protein B (GbpB) (GbpB)

Glucan-binding protein B (GbpB) is a secreted and cell-surface-associated protein produced by Streptococcus mutans, the primary causative agent of dental caries. GbpB is essential for bacterial viability, functioning as a peptidoglycan hydrolase that facilitates cell wall remodeling during growth and division (UniProt P0A3S2). Additionally, it binds to extracellular glucans, which are crucial for the formation of the dental biofilm and the stable attachment of bacteria to the tooth surface (PubMed: 11133764). Due to its critical role in biofilm architecture and its high immunogenicity, GbpB is a major target for the development of caries vaccines, particularly those aimed at inducing protective salivary IgA responses (PubMed: 12692275). Experimental strategies involve using recombinant GbpB or its immunogenic peptides to prevent S. mutans colonization and subsequent tooth decay. Beyond its role in the oral cavity, GbpB has been implicated in the pathogenesis of infective endocarditis when S. mutans enters the bloodstream. Therapeutic interventions targeting GbpB aim to disrupt the structural integrity of the biofilm and the bacterial cell wall, thereby reducing the virulence of S. mutans. Research into GbpB also explores its potential as a biomarker for caries risk, as levels of the protein and corresponding antibodies correlate with disease activity.

Other names

GbpBSecreted glucan-binding protein BPeptidoglycan hydrolase GbpBStreptococcus mutans GbpB

Induction of mucosal IgA antibodies to inhibit bacterial adhesion and biofilm formation; inhibition of peptidoglycan hydrolase activity to disrupt cell wall maintenance and bacterial growth.