Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glucocerebrosidase (GCase)
- Target
- GCase
- Molecular classification
- Enzyme, Glycoside hydrolase
01
Overview
Glucocerebrosidase (GCase) is a lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide into ceramide and glucose. It is encoded by the GBA1 gene. Deficiency in GCase activity leads to Gaucher disease and is also a risk factor for Parkinson's disease. Therapeutic strategies include enzyme replacement therapy (ERT) and substrate reduction therapy (SRT).
- Other names
- β-glucocerebrosidaseAcid β-glucosidaseD-glucosyl-N-acylsphingosine glucohydrolase
02
Mechanism of action
Hydrolyzes glucosylceramide into ceramide and glucose.
03
Biological functions
Glycolipid catabolismHydrolysis of glucosylceramideHydrolysis of glucosylsphingosineSkin barrier formation
04
Disease associations
Gaucher diseaseParkinson's disease
05
Safety considerations
Infusion reactions (ERT)Neurological side effects (substrate reduction therapy)
06
Interacting drugs
Imiglucerase
4 more in the full profile.
07
Biomarkers
Glucosylceramide levelsGlucosylsphingosine levelsGCase enzyme activity
Beyond the preview
Go deeper on Glucocerebrosidase (GCase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glucocerebrosidase (GCase).