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Target intelligence / Profile preview
Glucocorticoid-induced TNFR-related Protein (GITR)
- Target
- GITR
- Molecular classification
- Tumor Necrosis Factor Receptor Superfamily, Type I transmembrane protein, Receptor
01
Overview
Glucocorticoid-induced TNFR-related protein (GITR), also known as TNFRSF18 and CD357, is a type I transmembrane protein belonging to the tumor necrosis factor receptor superfamily. It acts as a co-stimulatory molecule, influencing T cell activation, proliferation, and survival. GITR is highly expressed on regulatory T cells and inducibly expressed on effector T cells. Its interaction with GITRL on antigen-presenting cells and other non-lymphoid cells delivers co-stimulatory signals, modulating immune responses and playing a role in autoimmune diseases, cancer, and inflammation.
- Other names
- AITRCD357TNFRSF18
02
Mechanism of action
Agonists and antagonists targeting GITR modulate T cell activation and regulatory function.
03
Biological functions
T cell co-stimulationRegulation of T cell activation, proliferation, and survivalModulation of regulatory T-cell functionMacrophage activationImmune responseInflammation
04
Disease associations
Autoimmune diseases (e.g., rheumatoid arthritis)CancerInflammationAsthmaCollagen-induced arthritis
05
Safety considerations
Potential for exacerbating inflammatory conditionsPossible off-target effects on immune cellsComplex and context-dependent role in immune regulation
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