Glucocorticoid-Induced Tumor Necrosis Factor Receptor (GITR)

GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor), also known as TNFRSF18, CD357, or AITR, is a type I transmembrane protein and a member of the TNF receptor superfamily. It is constitutively expressed on regulatory T cells and upregulated on activated T cells. GITR interacts with its ligand GITRL, primarily expressed on antigen-presenting cells. GITR signaling plays a complex role in regulating immune responses, acting as a co-stimulatory signal for effector T cells, modulating the suppressive function of regulatory T cells, and regulating NK cell activity. It is implicated in cancer immunity, autoimmunity, inflammation, and cardiovascular disease.

Other names

TNFRSF18CD357AITR (Activation-Inducible TNFR Family Receptor)

GITR engagement provides co-stimulatory signals, modulates regulatory T cell suppression, and/or regulates NK cell activity depending on the cell type and context.