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Target intelligence / Profile preview
Glucocorticoid modulatory element-binding protein 1 (GMEB1)
- Target
- GMEB1
- Molecular classification
- Transcription factor, DNA-binding protein
01
Overview
Glucocorticoid modulatory element-binding protein 1 (GMEB1) is a transcription factor that binds glucocorticoid modulatory elements (GME) in promoters such as the tyrosine aminotransferase (TAT) gene, modulating sensitivity to glucocorticoid signaling. It commonly forms a complex with GMEB2, essential for parvovirus DNA replication, and has roles in both transcription coactivation and the inhibition of apoptosis. Overexpression of GMEB1 has been linked to enhanced tumor cell proliferation, migration, and resistance to apoptosis, notably in hepatocellular carcinoma. GMEB1 has also been implicated as a potential biomarker and therapeutic target in various cancers and is associated with certain neurodegenerative diseases.
- Other names
- GMEB1KDWK1
02
Mechanism of action
Modulation of gene transcription (including glucocorticoid receptor activity), Promotion of anti-apoptotic signaling, Co-activator functions in DNA replication (e.g., parvovirus replication)
03
Biological functions
Transcription regulationApoptosis inhibitionCell proliferationViral replication
04
Disease associations
CancerInflammationNeurodegenerative disease (e.g., association with Parkinson's disease)Other
05
Safety considerations
Potential for oncogenic effects if overexpressedInvolvement in anti-apoptotic pathways may complicate cancer therapies or immune responses
06
Biomarkers
Overexpression is a proposed diagnostic and prognostic biomarker in hepatocellular carcinoma and potentially other cancers
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