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Target intelligence / Profile preview
Glucocorticoid Receptor (GR)
- Target
- GR
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
The glucocorticoid receptor (GR), also known as NR3C1, is a member of the nuclear receptor superfamily of ligand-dependent transcription factors. It mediates the physiological and pharmacological actions of glucocorticoids, which are steroid hormones essential for life and involved in regulating numerous processes such as metabolism, development, immune response, inflammation, and stress adaptation.
- Other names
- NR3C1
02
Mechanism of action
Ligand binding induces a conformational change, dissociation of chaperone proteins, translocation to the nucleus, and either transactivation via GREs or transrepression/tethering via interaction with other transcription factors.
03
Biological functions
Developmental processesMetabolism regulationImmune responseInflammatory pathwaysCellular proliferationCellular differentiationChromatin remodelingStress adaptationHomeostasis
04
Disease associations
AllergiesAsthmaAutoimmune diseasesAdrenal insufficiencyOrgan transplantation rejectionCancerInflammation
05
Safety considerations
ImmunosuppressionMetabolic disturbancesIncreased risk of infectionAdrenal suppressionOsteoporosisCushing's syndrome-like symptomsPsychiatric disturbances
06
Interacting drugs
Cortisol
1 more in the full profile.
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