Target intelligence / Profile preview

Glucokinase (GK)

Target: GK
Molecular classification: Enzyme

Overview

Glucokinase (GK), also known as hexokinase IV or hexokinase D, is a key enzyme in glucose metabolism and homeostasis. It catalyzes the phosphorylation of glucose to glucose-6-phosphate (G6P), the first step in both glycogen synthesis and glycolysis in the liver and pancreas. It acts as a glucose sensor, especially in pancreatic β-cells for insulin release regulation, but also plays roles in other cells involved in overall glucose homeostasis.

Other names: Hexokinase IVHexokinase D

Mechanism of action

Glucokinase activators increase the activity of glucokinase, leading to increased glucose metabolism and insulin secretion.

Biological functions

Phosphorylation of glucose to glucose-6-phosphateRegulation of glycolysisRegulation of glycogenesisRegulation of insulin secretionBlood sugar sensing

Disease associations

Maturity-onset diabetes of the young type II (MODY-II)Persistent hyperinsulinemic hypoglycemia of infancy

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