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Glucolipid metabolism pathway

Molecular classification
Other
01

Overview

Glucolipid metabolism pathway" refers to the integrated biochemical network responsible for the regulated processing of both glucose and lipids within cells and across organ systems. This network is fundamental for cellular energy production, storage, and utilization and involves enzymes, transporters, receptors, and signaling molecules that maintain homeostasis of blood sugar and fat levels. Dysregulation of these pathways is central to the pathogenesis of metabolic diseases such as diabetes, obesity, nonalcoholic fatty liver disease (NAFLD), and cardiovascular diseases[4][5][6]. Rather than a specific protein or drug target, "glucolipid metabolism pathway" encompasses numerous proteins, such as acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), glucose transporter type 2 (GLUT2), and transcription factors like ATF3, which collectively regulate these metabolic processes[3][4].

Other names
Glucose and lipid metabolism pathwayGlucolipid metabolic pathwayCarbohydrate and lipid metabolism
02

Biological functions

Energy homeostasisCellular biosynthesisSignal transductionMaintenance of membrane structure
03

Disease associations

Diabetes mellitusObesityCardiovascular diseaseNonalcoholic fatty liver diseaseOther metabolic diseases
04

Biomarkers

Fasting insulin (FINS)Fasting C-peptide (FCP)Triglyceride-glucose index (TyG)2-hour insulin (2hINS)

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