Target intelligence / Profile preview

Glucomannan fiber

Molecular classification
Other (soluble dietary fiber, polysaccharide, hemicellulose)
01

Overview

Glucomannan fiber is a high-molecular-weight, water-soluble dietary polysaccharide extracted primarily from the tubers of the konjac plant (Amorphophallus konjac), consisting mainly of D-mannose and D-glucose monomers in a roughly 1.6:1 ratio, linked via β-1,4 glycosidic bonds. It is notable for its extremely high viscosity and ability to absorb water and form a gel, which underlies its effects as a bulking laxative, an agent that promotes satiety for weight control, and a cholesterol-lowering supplement. It is not a cellular or protein-based therapeutic target, but rather a bulk-acting dietary fiber with beneficial and mechanical effects in the gastrointestinal tract. Common side effects include gastrointestinal discomfort and, rarely, obstruction if not taken with adequate fluids.

Other names
Konjac glucomannanKonjac mannanKonjac fiberKonjac flourGlucomannan powder
02

Mechanism of action

Mechanical bulk-forming effect: absorbs water, swells, and forms a gel that slows gastric emptying, carbohydrate/sugar/fat absorption, and provides satiety. Binds dietary cholesterol and bile acids in the intestine, leading to reduced absorption and lower serum cholesterol. Acts as a prebiotic fiber, altering gut microbiota composition.

03

Biological functions

Increases satiety by forming a viscous gel in the stomach and intestineSlows gastric emptying and absorption of nutrients (especially glucose)Reduces cholesterol absorption and bile acid reabsorptionPromotes bowel regularity (laxative effect)Prebiotic effect (feeds beneficial gut microbes)
04

Disease associations

Obesity (used in weight management products)Hypercholesterolemia (lowers LDL cholesterol)ConstipationDiabetes (improves glycemic control)Other (may reduce cardiovascular risk factors)
05

Safety considerations

Choking and esophageal/gastrointestinal obstruction risk if not taken with enough waterGastrointestinal side effects: flatulence, bloating, abdominal discomfort, diarrhea or loose stoolsMay decrease absorption/bioavailability of orally administered drugs or nutrients when taken simultaneously
06

Interacting drugs

oral medications

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