Glucoregulatory metabolic pathways

Glucoregulatory metabolic pathways are a set of interconnected biochemical routes responsible for maintaining glucose levels within organisms. Major pathways include glycolysis, gluconeogenesis, and glycogen metabolism, each regulated by specific enzymes, transporters, and hormonal signals. These pathways dictate cellular energy production, storage, and utilization, while feedback and gene expression systems enable adaptation to physiological demands. They are disrupted in various metabolic diseases and are exploited as therapeutic targets, particularly in diabetes, obesity, and cancer[1][3][4]. In summary, "Glucoregulatory metabolic pathways" is not a canonical molecule or receptor, but an umbrella term for a group of pathways; thus, it is not a drug target in singular form[1][3]. For molecular drugs or targets, individual enzymes, transporters, or receptors within these pathways (e.g., GLUTs, hexokinase, glucokinase, insulin receptor) should be specified.

Other names

glucose metabolismcarbohydrate metabolismenergy-yielding pathways for glucose

Enzyme inhibition (e.g., hexokinase, phosphofructokinase, pyruvate kinase); Modulation of glucose transport; Alteration of hormonal signaling (insulin, glucagon, etc.); Feedback inhibition in metabolic steps