Glucosamine-6-phosphate deaminase 2 (GNPDA2)

Glucosamine-6-phosphate deaminase 2 (GNPDA2) is a human enzyme encoded by the GNPDA2 gene on chromosome 4[2][4]. It catalyzes the reversible conversion of glucosamine-6-phosphate (GlcN-6P) to fructose-6-phosphate (Fru-6P) and ammonium ion, a key regulatory reaction in the hexosamine biosynthesis pathway[2][3][7]. This pathway connects glucose metabolism to the generation of UDP-N-acetylglucosamine, influencing cellular protein glycosylation, signaling, and tissue remodeling[2][6]. GNPDA2 is involved in lipid and glucose metabolism and may enhance adipogenesis[3][6]. Genome-wide association studies have consistently implicated GNPDA2 loci in susceptibility to obesity and type 2 diabetes, with most evidence based on epidemiological genetics; experimental studies are fewer but support a metabolic role for GNPDA2[6]. It is mainly classified as an enzyme and has no established known direct pharmacological modulators or interacting drugs[3][6]. The gene's function and regulation are under active investigation as part of research into metabolic disorders and obesity.

Other names

GNP2SB52GlcN6P deaminase 2glucosamine-6-phosphate isomerase 2glucosamine-6-phosphate isomerase SB52Glucosamine-6-phosphate deaminase 2