Phosphoglucomutase 2-like protein 1 (PGM2L1)

Phosphoglucomutase 2-like protein 1 (PGM2L1) is a specialized enzyme that serves as the primary glucose 1,6-bisphosphate (G16BP) synthase in mammalian cells (UniProt: Q6PCE3). It catalyzes the synthesis of G16BP from glucose 1-phosphate and glucose 6-phosphate, creating a potent allosteric effector that activates phosphofructokinase-1 and inhibits hexokinase (PubMed: 17666396). Through this mechanism, PGM2L1 acts as a critical metabolic rheostat, modulating the rate of glycolysis and directing carbohydrate flux based on cellular energy needs. In addition to its synthase activity, the protein exhibits 1,3-bisphosphoglycerate phosphatase activity, further integrating it into the regulation of glycolytic intermediates (NCBI Gene: 283209). While PGM2L1 is not currently the target of any approved therapeutics, its role in metabolic reprogramming makes it a significant subject of interest in oncology and the study of rare metabolic disorders (PubMed: 30216300). Understanding the regulation of PGM2L1 is essential for deciphering how cells maintain glucose homeostasis and adapt to metabolic stress.

Other names

Glucose 1,6-bisphosphate synthasePMMH1BM-007Phosphopentomutase 2-like protein 1