Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
- Target
- G6PC1
- Molecular classification
- Enzyme, Phosphatase, Membrane protein
01
Overview
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and inorganic phosphate. This reaction is the final step in both gluconeogenesis and glycogenolysis, making G6PC1 a key regulator of glucose homeostasis. Variants in G6PC1 cause Glycogen Storage Disease Type Ia (GSDIa; von Gierke disease). Overexpression or dysregulation may contribute to altered hepatic glucose output seen in diabetes mellitus.
- Other names
- Glucose-6-phosphatase alphaGSD1AGSDIa
02
Mechanism of action
Inhibition of glucose-6-phosphatase activity
03
Biological functions
GluconeogenesisGlycogenolysisGlucose homeostasis
04
Disease associations
Glycogen Storage Disease Type Ia (GSDIa; von Gierke disease)Diabetes mellitusCancer
05
Safety considerations
HypoglycemiaLactic acidosisHyperuricemiaHyperlipidemiaKidney dysfunctionGrowth retardation
06
Biomarkers
Glucose-6-phosphate levelsBlood glucose levelsLactic acid levelsUric acid levelsLipid levels
Beyond the preview
Go deeper on Glucose-6-phosphatase catalytic subunit 1 (G6PC1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glucose-6-phosphatase catalytic subunit 1 (G6PC1).