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Target intelligence / Profile preview
Glucose-6-phosphatase catalytic subunit 2 (G6PC2)
- Target
- G6PC2
- Molecular classification
- Enzyme, Phosphatase, Integral membrane protein
01
Overview
Glucose-6-phosphatase catalytic subunit 2 (G6PC2), also known as IGRP, is an enzyme predominantly expressed in pancreatic β-cells. It modulates glycolytic flux and fine-tunes basal insulin secretion sensitivity by forming a substrate cycle with glucokinase. Genetic variation affects fasting glycemia risk and it serves as an autoimmune target relevant for type 1 diabetes pathogenesis.
- Other names
- IGRPIslet-specific glucose-6-phosphatase catalytic subunit-related proteinglucose-6-phosphatase catalytic subunit 2
02
Mechanism of action
Modulation of glucose-6-phosphate hydrolysis to regulate glycolytic flux and insulin secretion
03
Biological functions
Glucose metabolismRegulation of insulin secretionGlycolytic flux modulation
04
Disease associations
Type 1 diabetes mellitusFasting blood glucose regulation
05
Safety considerations
Potential for dysregulation of insulin secretionAutoimmune response in type 1 diabetes
06
Biomarkers
Fasting blood glucose levelsG6PC2 autoantibodies
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