Glucose metabolism regulation pathway

The glucose metabolism regulation pathway encompasses a complex system of biological processes and regulatory controls that maintain blood glucose levels and provide energy to tissues. This system includes the absorption, transport, storage, and utilization of glucose through interconnected pathways such as glycolysis (breakdown of glucose), gluconeogenesis (formation of glucose), glycogenesis (storage as glycogen), and glycogenolysis (mobilization of glycogen)[7][5][3][4]. Regulation is achieved through acute and chronic mechanisms, including the control of enzyme activity by hormones (mainly insulin and glucagon), allosteric effectors, post-translational modifications, and transcriptional regulation via transcription factors (such as CREB, FOXO1, and ChREBP)[1][6][4]. Disruption of this regulation is central to the development of metabolic diseases, including diabetes and obesity. The pathway itself is not a single druggable target, but rather a collection of interacting molecules, each of which can serve as a therapeutic target in metabolic disease[7]. Key point: "Glucose metabolism regulation pathway" refers to a regulatory network or group of interconnected pathways, not to a discrete molecule, protein, or canonical drug target, so it does not meet the criteria for a canonical therapeutic target or molecular entity[7][3][4][1].

Other names

Glucose homeostasis pathwayRegulation of glucose metabolism

Stimulate or inhibit insulin signaling; Enhance or suppress hepatic gluconeogenesis; Increase glucose uptake in peripheral tissues; Inhibit renal glucose reabsorption; Modulate activity of enzymes and transcription factors involved in glucose metabolism