Target intelligence / Profile preview

Glucose Metabolism Pathways (GMP)

Target
GMP
Molecular classification
Enzymes, Transporters
01

Overview

Glucose metabolism pathways, including glycolysis, the pentose phosphate pathway, and oxidative phosphorylation, play a crucial role in energy production and cellular functions. These pathways are often reprogrammed in cancer cells to support rapid proliferation and survival, making them attractive targets for cancer therapy. Drugs targeting these pathways can modulate glucose uptake and metabolism, affecting tumor growth and survival.

Other names
Glucose metabolic pathwaysGlycolytic pathwaysGlucometabolic pathways
02

Mechanism of action

Inhibition of glucose uptake (e.g., SGLT2 inhibitors), modulation of glycolytic enzymes, interference with signaling pathways (e.g., Akt)

03

Biological functions

Energy productionCell proliferationSignal transductionApoptosis regulation
04

Disease associations

CancerMetabolic disordersNeurodegenerative diseases
05

Safety considerations

HypoglycemiaImpact on normal cell metabolismPotential for resistance development
06

Interacting drugs

Canagliflozin

1 more in the full profile.

07

Biomarkers

Glucose levelsLactate levelsExpression of glucose transporters (e.g., GLUT1)

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