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Target intelligence / Profile preview
Endoplasmic Reticulum Homologue GP96 (GP96)
- Target
- GP96
- Molecular classification
- Heat Shock Protein, HSP90 family, Molecular chaperone, ATPase
01
Overview
GP96 is a major endoplasmic reticulum (ER)-resident heat shock protein and a paralog of HSP90. It functions as an ATP-dependent molecular chaperone, playing essential roles in protein folding, quality control, and cellular homeostasis. It is induced by the accumulation of misfolded proteins in the ER. GP96 is also involved in immune system modulation, particularly in antigen presentation and dendritic cell activation, bridging innate and adaptive immunity. It plays a pro-oncogenic role, especially in liver cancer.
- Other names
- gp96grp94glucose-regulated protein 94endoplasminERp99
02
Biological functions
Protein foldingQuality controlCellular homeostasisAntigen presentationDendritic cell activationImmune system modulationChaperoning
03
Disease associations
CancerLiver cancer
04
Safety considerations
Essential gene - complete loss of function is embryonically lethal
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