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Glucose Transporter 3 (GLUT3)

Target: GLUT3
Molecular classification: Transporter, Facilitative sugar transporter, Membrane protein

Overview

Glucose transporter 3 (GLUT3) is a member of the facilitative glucose transporter family, primarily responsible for transporting glucose across plasma membranes in mammalian cells. It is most notably expressed in neurons, where it plays a critical role in supplying energy to neuronal tissue. It has the highest affinity for glucose among Class I transporters, ensuring preferential glucose uptake by neurons. Defects or reduced expression are associated with neurodegenerative diseases.

Other names: SLC2A3

Mechanism of action

Facilitated diffusion of glucose across the cell membrane

Biological functions

Glucose transportNeuronal energy supply

Disease associations

Neurodegenerative diseaseAlzheimer's Disease

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