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Glucose Transporter 9 (GLUT9)
- Target
- GLUT9
- Molecular classification
- Transporter, Solute Carrier Family 2 (SLC2)
01
Overview
Glucose Transporter 9 (GLUT9), encoded by the SLC2A9 gene, is a facilitative hexose transporter primarily expressed in the kidney and liver. It plays a crucial role in uric acid homeostasis by mediating the reabsorption of urate in the proximal tubules of the kidney. GLUT9 also transports glucose and fructose. Genetic variations in SLC2A9 are strongly associated with serum uric acid levels and an increased risk of gout and other metabolic disorders.
- Other names
- GLUT-9GLUTXhuman glucose transporter-like protein-9solute carrier family 2 (facilitated glucose transporter), member 9SLC2A9UAQTL2urate voltage-driven efflux transporter 1 (URATv1)
02
Mechanism of action
Facilitated transport of glucose, fructose, and urate across cell membranes.
03
Biological functions
Glucose transportFructose transportUric acid transportUrate homeostasisRenal reabsorption
04
Disease associations
GoutMetabolic syndromeObesityDiabetes mellitusHypertensionChronic renal failureHypouricemiaNephrolithiasisKidney inflammationKidney fibrosis
05
Safety considerations
Altered uric acid levels can lead to gout or kidney complicationsPotential for drug interactions affecting uric acid transport
06
Biomarkers
Serum uric acid levelsUrinary uric acid excretion
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