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Glucose Transporter Protein Family (GLUTs)
- Target
- GLUTs
- Molecular classification
- Transporter, Membrane protein, Solute Carrier
01
Overview
The glucose transporter protein family consists of membrane proteins that facilitate the transport of glucose and related hexoses across cellular membranes. These proteins are essential for cellular energy supply, metabolic regulation, and tissue-specific functions. In humans, this family is primarily known as the GLUT (glucose transporter) or SLC2A (solute carrier family 2) gene family. Defects/mutations cause various diseases including glucose transporter type I deficiency syndrome, and impaired expression/function is implicated in diabetes mellitus. Overexpression or altered localization may be seen in cancer cells.
- Other names
- Solute Carrier Family 2 (SLC2A)GLUT1GLUT2GLUT3GLUT4GLUT5GLUT6GLUT7GLUT8GLUT9GLUT10GLUT11GLUT12GLUT13GLUT14
02
Mechanism of action
Facilitated diffusion of glucose and other hexoses across cell membranes
03
Biological functions
Glucose transportFructose transportHexose transportBlood glucose homeostasisCellular energy supplyMetabolic regulation
04
Disease associations
Diabetes mellitusGlucose transporter type I deficiency syndromeCancerArterial tortuosity syndrome
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