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Glucose Transporter Type 1 (GLUT1)
- Target
- GLUT1
- Molecular classification
- Sugar Porter family (SP family), Transporter
01
Overview
GLUT1 is a facilitative glucose transporter protein encoded by the SLC2A1 gene. It is a uniporter that enables the passive transport of glucose across plasma membranes, playing a critical role in cellular energy supply, especially in tissues with high metabolic demand such as erythrocytes and the blood-brain barrier. Mutations or deficiencies in SLC2A1 cause Glut1 Deficiency Syndrome (GDS) resulting from impaired glucose transport into the brain and are characterized by seizures, developmental delay and movement disorders.
- Other names
- SLC2A1GLUT1 deficiency syndromeGDSDe Vivo Disease
02
Mechanism of action
Inhibition of glucose transport
03
Biological functions
Glucose transportFacilitative diffusionVitamin C recyclingCellular energy supply
04
Disease associations
Glut1 Deficiency SyndromeIdiopathic generalized epilepsy type 12Dystonia type 9
05
Safety considerations
Impaired glucose transport into the brain
06
Interacting drugs
Cytochalasin B
5 more in the full profile.
07
Biomarkers
Glucose levels in cerebrospinal fluid
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