Glucosinolate metabolism pathway

The glucosinolate metabolism pathway encompasses the enzymatic biosynthesis, modification, transport, and degradation of glucosinolates, a group of sulfur- and nitrogen-containing secondary metabolites primarily found in Brassicaceae vegetables. Biosynthesis starts from amino acid precursors (e.g., methionine, tryptophan, or phenylalanine), proceeding through chain elongation, core structure formation, and secondary modifications mediated by various enzymes (e.g., cytochrome P450s, methylthioalkylmalate synthases, glycosyltransferases, and sulfotransferases)[1][2][3]. Breakdown of glucosinolates, usually triggered by tissue damage or pathogen attack, involves myrosinase enzymes, producing bioactive compounds such as isothiocyanates, nitriles, and thiocyanates, which play key roles in plant defense and are linked to human health benefits[1][3][4][6]. The pathway is regulated by genetic and environmental factors, with specific enzymes and transcription factors controlling pathway dynamics[2][7].

Other names

glucosinolate biosynthetic pathwayglucosinolate hydrolysis pathway