Streptococcal glucosyltransferase (Gtf (general); GtfB, GtfC, GtfD (specific enzymes))

Streptococcal glucosyltransferase refers to a family of enzymes (primarily GtfB, GtfC, and GtfD) produced by *Streptococcus mutans* and related oral streptococci[5][6][7]. These enzymes catalyze the transfer of glucose residues from sucrose to form extracellular glucans, which are key structural components of dental biofilms and are essential for bacterial colonization and virulence in dental caries[5][7]. Gtfs belong to glycoside hydrolase family 70 and share a conserved catalytic domain (for sucrose binding and cleavage) with a variable C-terminal region for glucan binding[7]. They are well-recognized therapeutic targets for caries prevention and control strategies focused on disrupting biofilm formation. Inhibitors of Gtfs are being explored as anticaries agents, but clinical translation is complicated by selectivity and safety considerations[5][6][7].

Other names

GlucosyltransferaseGtfdextransucraseGTaseGtfBGtfCGtfD

Drugs/inhibitors block enzymatic activity, suppressing synthesis of water-soluble and water-insoluble glucans, thus reducing biofilm formation[5][6]