Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate (GLU)
- Target
- GLU
- Molecular classification
- Neurotransmitter, Amino Acid, Metabolite
01
Overview
Glutamate is the most abundant excitatory neurotransmitter in the vertebrate nervous system. It plays a central role in neural activation, protein biosynthesis, and intermediary metabolism. Dysregulation of glutamate signaling is implicated in various neurological disorders. Glutamate acts on ionotropic receptors (NMDA, AMPA, Kainate) and metabotropic receptors (mGluRs).
- Other names
- L-glutamateHydrogen glutamate2-amino pentanedioic acidAlpha-aminoglutaric acidL-glutamic acid anion
02
Mechanism of action
Modulation of glutamate receptors (NMDA, AMPA, Kainate, mGluRs)
03
Biological functions
NeurotransmissionExcitatory neurotransmissionProtein biosynthesisIntermediary metabolismGABA synthesis precursor
04
Disease associations
Neurodegenerative diseaseEpilepsyStrokeTraumatic brain injuryExcitotoxicity
05
Safety considerations
ExcitotoxicitySeizuresNeurodegeneration
06
Interacting drugs
AP5
6 more in the full profile.
Beyond the preview
Go deeper on Glutamate (GLU).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate (GLU).