Glutamate-ammonia ligase pseudogene 3 (GLULP3)

Glutamate-ammonia ligase pseudogene 3 (GLULP3) is a genomic DNA sequence in humans that represents a nonfunctional copy (pseudogene) of the gene encoding glutamate-ammonia ligase (glutamine synthetase). Unlike the active enzyme, pseudogenes such as GLULP3 lack the ability to encode a functional protein due to disabling mutations, deletions, or rearrangements. Pseudogenes may have regulatory functions at the RNA level but generally do not serve as drug targets or have major biological roles. There is no evidence that GLULP3 encodes an active receptor, transporter, or enzyme, nor is it linked to any diseases, drug action, or clinical biomarker use[3]. GLULP3 should not be confused with the functional **glutamate-ammonia ligase (GLUL)** enzyme, which does play significant biological roles in nitrogen metabolism. The presence of "pseudogene" in its name indicates that this specific entry is non-functional with respect to its protein-coding potential[3].

Other names

GLUL pseudogene 3GLULP3

Not applicable; as a pseudogene, there is no mechanism of action for drugs.