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Target intelligence / Profile preview
Glutamic Acid Decarboxylase 65 (GAD65)
- Target
- GAD65
- Molecular classification
- Enzyme
01
Overview
Glutamic acid decarboxylase 65 (GAD65) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the central nervous system. GAD65 is one of two major isoforms of glutamate decarboxylase and is a key autoantigen in type 1 diabetes and several neurological autoimmune disorders.
- Other names
- GAD2Glutamic acid decarboxylaseGlutamate decarboxylaseGADGADA
02
Biological functions
NeurotransmissionGABA synthesisInsulin secretion regulation
03
Disease associations
Type 1 Diabetes MellitusLatent Autoimmune Diabetes in Adults (LADA)Stiff-person syndromeCerebellar ataxiaLimbic encephalitisEpilepsyPolyendocrine syndromes
04
Safety considerations
Autoimmune responseCross-reactivity with dietary and viral antigens
05
Biomarkers
Anti-GAD65 antibodies
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