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Target intelligence / Profile preview
Glutamate decarboxylase 2 (GAD2)
- Target
- GAD2
- Molecular classification
- Enzyme, Carboxy-Lyase
01
Overview
Glutamate decarboxylase 2 (GAD2) is an enzyme that catalyzes the decarboxylation of L-glutamic acid to produce gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. It is a major autoantigen implicated in several autoimmune diseases, including Type I diabetes mellitus and Stiff-person syndrome.
- Other names
- GAD65glutamic acid decarboxylase 65 kDa isoformGAD-65
02
Biological functions
Synthesis of neurotransmitter gamma-amino butyric acid (GABA)One-carbon metabolismGeneral gene expression/transcription regulation
03
Disease associations
Type I diabetes mellitusStiff-person syndromeGraves diseaseAutoimmune polyendocrine syndromes
04
Biomarkers
Autoantibodies against GAD65 (early detection/risk assessment of Type I diabetes mellitus)Autoantibodies against GAD65 (diagnosis/supportive evidence for stiff-person syndrome)
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