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Target intelligence / Profile preview
Glutamate-gated Chloride Channel (GluCl)
- Target
- GluCl
- Molecular classification
- Pentameric ligand-gated ion channel (pLGIC), Cys-loop receptor, Ion channel, Receptor
01
Overview
Glutamate-gated chloride channels (GluCls) are ligand-gated ion channels found exclusively in protostome invertebrates, such as nematodes and arthropods. They are structurally related to mammalian glycine receptors but do not occur in vertebrates. Upon binding of glutamate, these channels open to allow chloride ions to flow across cell membranes, hyperpolarizing neurons or muscle cells and exerting inhibitory effects on neural circuits. GluCls are major targets of macrocyclic lactone anthelmintics (e.g., ivermectin), which lock the channel open, causing persistent inhibition that paralyzes and kills parasites.
02
Mechanism of action
Macrocyclic lactones bind to GluCls, locking the channel open, causing chloride influx, hyperpolarization, and paralysis of invertebrates.
03
Biological functions
Inhibitory neurotransmissionRegulation of locomotionRegulation of feeding behaviorSensory input modulation
04
Disease associations
Parasitic infections
05
Safety considerations
Potential for resistance development in parasitesSpecies selectivity needed to avoid off-target effects in non-target invertebrates
06
Interacting drugs
Ivermectin
2 more in the full profile.
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