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Target intelligence / Profile preview
Glutamate-gated chloride channel (invertebrate) (GluCl)
- Target
- GluCl
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor
01
Overview
Glutamate-gated chloride channels are unique inhibitory neurotransmitter receptors exclusive to protostome invertebrates. They play essential roles in nervous system function by mediating fast synaptic inhibition via chloride influx upon activation by glutamate. Their unique presence outside vertebrates makes them highly effective targets for selective anti-parasitic agents such as ivermectin—a cornerstone drug against several major human parasitic diseases—and important tools for pest control due to their role across many agricultural pests. Their structure-function relationship has provided significant insight into the broader Cys-loop receptor family biology.
02
Mechanism of action
Allosteric agonist; increases chloride ion influx, leading to hyperpolarization and paralysis.
03
Biological functions
Synaptic inhibitionRegulation of locomotionRegulation of feedingSensory input processing
04
Disease associations
Parasitic infectionsPest control
05
Safety considerations
Potential for resistance development in parasitesNeurotoxicity at high doses in mammals (due to off-target effects)
06
Interacting drugs
Ivermectin
1 more in the full profile.
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