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Glutamate-gated chloride ion channel alpha-type subunit (GluClα)
- Target
- GluClα
- Molecular classification
- Ligand-gated ion channel, Ion channel, Receptor
01
Overview
The glutamate-gated chloride ion channel alpha-type subunit, encoded by the Avr-14 gene, is a member of the ligand-gated ion channel superfamily found in invertebrates. This protein forms part of a pentameric receptor complex that mediates inhibitory neurotransmission by allowing chloride ions to flow across cell membranes upon activation by extracellular glutamate. It is a primary target for macrocyclic lactone drugs such as ivermectin, and mutations in Avr-14 can confer resistance to these drugs.
- Other names
- Avr-14 gene productAVR-14AAVR-14B
02
Mechanism of action
Allosteric modulation leading to persistent channel opening and chloride influx, causing hyperpolarization and paralysis.
03
Biological functions
Inhibitory neurotransmissionNeural signalingChloride ion transport
04
Disease associations
Parasitic infectionsIvermectin resistance
05
Safety considerations
Development of drug resistance in parasitesPotential for off-target effects, although the channel is not present in vertebrates
06
Interacting drugs
Ivermectin
1 more in the full profile.
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