Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate ionotropic receptor AMPA type subunit 1 (GRIA1)
- Target
- GRIA1
- Molecular classification
- Ionotropic glutamate receptor, AMPA receptor, Ligand-gated ion channel
01
Overview
GRIA1 encodes a subunit of the ionotropic glutamate receptors of the AMPA type, which mediate fast excitatory synaptic transmission in the central nervous system. These receptors play critical roles in synaptic plasticity, underlying learning and memory. Dysfunction or altered expression of GRIA1 has been implicated in various neurological diseases.
- Other names
- Glutamate receptor 1GluR-K1GluR-AGluR-1GluA1GLUR1GLUH1AMPA-selective glutamate receptor 1
02
Mechanism of action
Ligand-gated cation channel activation
03
Biological functions
Fast excitatory neurotransmissionSynaptic plasticityLong-term potentiationLearningMemory
04
Disease associations
Neurodevelopmental disordersCognitive deficits
Beyond the preview
Go deeper on Glutamate ionotropic receptor AMPA type subunit 1 (GRIA1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate ionotropic receptor AMPA type subunit 1 (GRIA1).