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Glutamate ionotropic receptor AMPA type subunit 2 (GluA2)

Target: GluA2
Molecular classification: Receptor, Ion channel, Ligand-gated ion channel

Overview

Glutamate receptor 2 (GluA2), encoded by the GRIA2 gene, is a subunit of AMPA-type ionotropic glutamate receptors (AMPARs). AMPARs mediate fast excitatory neurotransmission in the central nervous system. GluA2 plays a crucial role in regulating calcium permeability of AMPARs, with proper RNA editing preventing calcium influx. Defective RNA editing is implicated in neurodegenerative diseases like ALS due to altered calcium permeability and neuronal toxicity. Alternative splicing of GRIA2 affects receptor desensitization kinetics, modulating synaptic responses.

Other names: GLUR2GLURBGluR-2GluR-K2HBGR2gluR-BNEDLIB

Mechanism of action

Ligand-gated cation channel activation, mediating Na+ influx and synaptic transmission.

Biological functions

Fast excitatory synaptic transmissionSynaptic plasticityRegulation of neuronal developmentSignal transduction

Disease associations

Neurodegenerative diseaseAmyotrophic Lateral Sclerosis (ALS)

Safety considerations

Defective RNA editing leading to increased calcium permeability and neuronal toxicityPotential excitotoxicity from excessive AMPA receptor activation

Interacting drugs

AMPA

2 more in the full profile.

Biomarkers

RNA editing status of GRIA2 transcriptCalcium permeability of AMPARs

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