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Target intelligence / Profile preview
Glutamate ionotropic receptor kainate type subunit 2 (GRIK2)
- Target
- GRIK2
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel, Glutamate receptor, Kainate receptor
01
Overview
GRIK2 is a subunit of the kainate family of ionotropic glutamate receptors. It functions as a cation-permeable ligand-gated ion channel, mediating fast excitatory neurotransmission in the central nervous system. GRIK2 is involved in synaptic plasticity, learning, memory, and other neurological processes. Mutations in GRIK2 are associated with neurodevelopmental disorders characterized by intellectual disability, developmental delay, and epilepsy.
- Other names
- Ionotropic glutamate receptor 6GluR6GLUR6GluK2
02
Mechanism of action
Ligand-gated ion channel activation/modulation
03
Biological functions
Synaptic transmissionSynaptic plasticityLearningMemory formationNeurotransmissionSensory perception (cold sensation)Transmission of visual information
04
Disease associations
Neurodevelopmental disordersIntellectual disabilityDevelopmental delayEpilepsyWhite matter abnormalitiesHypomyelinationAutosomal recessive mental retardation
05
Safety considerations
Potential for off-target effects due to widespread expression in the CNSTherapeutic challenges related to subunit selectivity and heteromeric receptor composition
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