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Target intelligence / Profile preview
Glutamate ionotropic receptor NMDA type subunit 1 (GluN1)
- Target
- GluN1
- Molecular classification
- Receptor, Ion channel, Ionotropic glutamate receptor, NMDA receptor subunit
01
Overview
The glutamate ionotropic receptor NMDA type subunit 1 (GluN1), encoded by the GRIN1 gene, is an obligatory subunit of NMDA receptors. NMDA receptors are ligand-gated ion channels mediating excitatory neurotransmission in the central nervous system. GluN1 binds glycine or D-serine and is essential for receptor assembly and function, playing key roles in synaptic plasticity, learning, and memory. GRIN1 mutations are associated with severe neurodevelopmental disorders.
- Other names
- GRIN1NR1NRZNMDAR-Zetazeta-subunit
02
Mechanism of action
Ligand-gated ion channel activation
03
Biological functions
NeurotransmissionSynaptic plasticityLong-term potentiation (LTP)Long-term depression (LTD)LearningMemoryCalcium signalingRegulation of inflammation
04
Disease associations
Intellectual disabilityEpilepsyMovement disordersAutism spectrum disorderNeuropathic pain
05
Safety considerations
ExcitotoxicityNeurodevelopmental effects
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