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Glutamate Modulator (None)
- Target
- None
- Molecular classification
- Ionotropic Glutamate Receptor, AMPA Receptor, NMDA Receptor, Kainate Receptor, Metabotropic Glutamate Receptor (mGluR), G protein-coupled receptor
01
Overview
A glutamate modulator refers to any molecule, drug, or agent that influences the activity of glutamate—the primary excitatory neurotransmitter in the central nervous system—by acting on its receptors or regulating its synaptic concentration. These modulators can either enhance or inhibit glutamatergic signaling and are being investigated for their therapeutic potential in various neuropsychiatric and neurological disorders.
02
Mechanism of action
Modulate receptor activation/inhibition/allosterism/release/reuptake
03
Biological functions
NeurotransmissionSynaptic plasticityNeuronal excitabilityMemory formationLearning
04
Disease associations
DepressionSchizophreniaObsessive-Compulsive Disorder (OCD)EpilepsyNeurodegenerative diseases
05
Safety considerations
Potential for excitotoxicitySide effects may vary depending on the specific modulator and receptor subtype targeted
06
Interacting drugs
Riluzole
4 more in the full profile.
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