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Target intelligence / Profile preview
Glutamate oxaloacetate transaminase (GOT)
- Target
- GOT
- Molecular classification
- Enzyme, Transaminase
01
Overview
Glutamate oxaloacetate transaminase is a pyridoxal phosphate-dependent enzyme crucial for amino acid metabolism and energy production in cells. It exists in two main forms: GOT1 (cytoplasmic) and GOT2 (mitochondrial). Both forms play significant roles in the urea cycle and citric acid cycle, and they are involved in cell proliferation, particularly in cancer cells. GOT enzymes are potential therapeutic targets for cancer treatment due to their role in supporting tumor growth.
- Other names
- Aspartate transaminase (AST)Aspartate aminotransferaseGlutamic-aspartic transaminase
02
Mechanism of action
Inhibitors targeting GOT enzymes aim to disrupt amino acid metabolism and energy supply in cancer cells, potentially slowing tumor growth.
03
Biological functions
Amino acid metabolismUrea cycleCitric acid cycleCell proliferation
04
Disease associations
CancerNeurodegenerative diseases (e.g., early onset infantile encephalopathy)
05
Safety considerations
Inhibiting GOT enzymes could potentially disrupt normal metabolic processes, though specific safety concerns are still under investigation.
06
Interacting drugs
Currently, specific drugs targeting GOT are under research, particularly inhibitors for cancer treatment.
07
Biomarkers
Serum AST levels are commonly used as biomarkers for liver health.
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