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Target intelligence / Profile preview
Alanine Aminotransferase (ALT)
- Target
- ALT
- Molecular classification
- Enzyme, Aminotransferase
01
Overview
Alanine aminotransferase (ALT) is an enzyme primarily found in the liver and, to a lesser extent, in other tissues. It plays a crucial role in amino acid metabolism by catalyzing the reversible transfer of an amino group from L-alanine to α-ketoglutarate. Serum ALT measurement is widely used as a biomarker for liver health, with elevated levels indicating hepatocellular injury or damage.
- Other names
- Alanine transaminaseSGPTGPTSerum glutamic-pyruvic transaminaseGlutamate pyruvate transaminase
02
Mechanism of action
N/A
03
Biological functions
Amino acid metabolismCatalysisAlanine cycle
04
Disease associations
Liver diseaseHepatocellular injuryAlcohol-induced liver injuryNon-alcoholic fatty liver disease (NAFLD/MASLD)Non-alcoholic steatohepatitis (NASH)Viral hepatitis B/CAutoimmune hepatitisDrug-induced liver injuryHemochromatosisVascular diseases affecting the liverGenetic disorders impacting hepatic function
05
Safety considerations
Elevated ALT is sensitive but not specific, requiring further diagnostic workupElevated ALT indicates hepatocellular injury but does not specify the cause or severity of disease
06
Interacting drugs
Hepatotoxic medications
2 more in the full profile.
07
Biomarkers
Serum ALT levelsAST/ALT ratio
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