Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate receptor, ionotropic, delta 2-interacting protein 1 (GRID2IP)
- Target
- GRID2IP
- Molecular classification
- Scaffolding protein, Postsynaptic protein, PDZ domain-containing protein, Formin homology domain-containing protein, Other (not a receptor, enzyme, transporter, or ion channel)
01
Overview
Glutamate receptor, ionotropic, delta 2-interacting protein 1 (GRID2IP), also known as Delphilin, is a postsynaptic scaffolding protein primarily localized at parallel fiber-Purkinje cell synapses in the cerebellum[4][3][1][5]. It contains both PDZ and formin homology domains, allowing it to interact with glutamate receptor delta 2 (GRID2) and the actin cytoskeleton, organizing postsynaptic complexes and facilitating synaptic signaling and plasticity[2][4][3][1]. Variants of GRID2IP have been associated with certain neurodegenerative disorders, such as spinocerebellar ataxia, but it is not considered a direct pharmacological target[3].
- Other names
- DelphilinGRID2IPGlutamate receptor, ionotropic, delta 2-interacting protein 1Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1Delphilin, glutamate receptor, ionotropic, delta 2-interacting protein 1
02
Mechanism of action
None applicable. There are no known drugs targeting GRID2IP, so mechanisms of action cannot be listed
03
Biological functions
Links glutamate receptor delta 2 (GRID2) to the actin cytoskeleton at parallel fiber-Purkinje cell synapsesOrganizes postsynaptic signaling complexesMay influence synaptogenesis and synaptic plasticity via GRID2 signaling in Purkinje cellsOther: General postsynaptic structural support in cerebellar signaling
04
Disease associations
Spinocerebellar ataxia 18Cerebral amyloid angiopathy, ITM2B-related, type 2Other: Associated with cerebellar function and neurological diseases, but not a direct therapeutic target
Beyond the preview
Go deeper on Glutamate receptor, ionotropic, delta 2-interacting protein 1 (GRID2IP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate receptor, ionotropic, delta 2-interacting protein 1 (GRID2IP).