Glutamate receptor, metabotropic 8 pseudogene

This gene, identified as ENSG00000230386 or LOC402279, is a pseudogene related in sequence to the functional glutamate metabotropic receptor 8 (GRM8) gene. Pseudogenes are nonfunctional DNA segments that may originate from duplication or retrotransposition events. They are typically characterized by the accumulation of mutations that disrupt protein-coding potential, making them incapable of producing a functional receptor protein[4]. Unlike the active GRM8 gene—which encodes a G protein-coupled receptor involved in neural signal transduction and implicated in some neuropsychiatric and cancer phenotypes[1][2][3]—this pseudogene has no known protein product or defined biological or therapeutic function. If drug interactions, mechanistic pharmacology, or disease roles are suspected, these refer to the active GRM8 gene (not the pseudogene), which is a GPCR involved in neuronal signaling and associated with various pathologies; however, the pseudogene ENSG00000230386 itself is not a drug target and has no therapeutic relevance[4].

Other names

LOC402279ENSG00000230386Pseudogene similar to part of glutamate receptor, metabotropic 8Glutamate receptor, metabotropic 8 pseudogene