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Glutamate receptor AMPA subtype (None)
- Target
- None
- Molecular classification
- Ionotropic glutamate receptor, Ligand-gated ion channel, Receptor
01
Overview
The AMPA receptor is an ionotropic glutamate receptor subtype responsible for mediating fast excitatory neurotransmission in the central nervous system. It is a tetrameric complex composed of GluA1-4 subunits, which upon binding of glutamate, opens a cation channel permeable to sodium, and sometimes calcium, leading to rapid depolarization. AMPARs play critical roles in synaptic plasticity, learning, and memory, and are implicated in various neurological disorders.
- Other names
- AMPA receptorAMPARQuisqualate ReceptoriGluR
02
Mechanism of action
Agonist binding opens cation channel, allowing Na+ influx and depolarization; antagonists block agonist binding.
03
Biological functions
Rapid synaptic transmissionLearningMemory formationSynaptic plasticityExcitatory neurotransmission
04
Disease associations
Neurodegenerative diseaseEpilepsyIschemic strokePsychiatric disorders
05
Safety considerations
ExcitotoxicitySeizuresNeurological damage from overstimulation
06
Interacting drugs
AMPA
4 more in the full profile.
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